When I lived in Chicago, long long long ago, two of my favorite acoustic performers were Steve Goodman and John Prine. They were fast friends and often performed together. Here's one of Prine's best songs, Souvenirs. Following that is another song performed by Goodman.
Sadly, Steve Goodman died in 1984 from leukemia. What I didn't know is that he was diagnosed in 1969 -- which means that he was aware of the diagnosis even as he was building a (very successful) career.